Therapeutic Area

Inflammation
Our Inflammation related CRO services test therapeutics that limit and control chronic or acute inflammation.

Uncontrolled inflammation that causes tissue damage has driven the need for targeted immuno-modulators. There are multiple players in the inflammatory processes that can be modelled in vitro including standard cytokine release and inflammasome assays or more customised multicellular assays. Chronic inflammation associated with aging “Inflammaging” is an increasing focus of therapeutic intervention.

Example of key assays designed to test therapeutics that modulate drivers of acute and chronic inflammation:
  • Neutrophil: Respiratory Burst (ROS, Phagoburst), NETs
  • Epithelial: EMT, keratinocyte cytokine release, Epithelial interface-barrier integrity, tight junction, TEER, cytokine release. Epithelial/immune cell co-culture
  • Fibroblast: FMT
  • Monocyte: Inflammasome/LPS cytokine release
  • Microglia: Inflammasome/LPS, alpha-synuclein cytokine release; beta-amyloid phagocytosis
  • Macrophage: M1/M2 polarisation and function
  • Innate Lymphoid Cell: ILC1/2/3 phenotype and cytokine production
  • Basophil/ Eosinophil/Mast cell
  • CD4 T cell: Cytokine Release Assay-predictive toxicity
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What Our Partners say about Nexus

Our tailored approach to assay design and execution provides precise solutions for novel therapeutics, ensuring the success of your drug development programme. Visit our testimonial page to read how our immunology CRO services and collaborative efforts have helped our partners achieve quality outcomes to their immunology-focused enquiries.

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