Therapeutic Area

Autoimmunity

As an Immunology CRO providing Autoimmune related services we test therapeutics that modulate or potentially re-educate damaging immune responses to self.

Current drive is to find more targeted therapeutics rather than global immunosuppressants. Key assays are designed to test both small molecules and biologics such as cytokine neutralising antibodies, against the major drivers of autoimmunity including CD4 T cells, B cells and antigen presenting cells.

Example of key assays designed to test both small molecules and biologics in the search of targeted immunotherapies:

CD4 T cell: Th1/2/17 polarisation, Th17 function, Tr1/iTreg polarisation, nTreg suppression, Tfh, naïve, CM and EM phenotype/function, polyclonal and antigen-specific T cell proliferation and cytokine release

CD8 T cell: activation, proliferation and function. Polyclonal and antigen-specific T cell responses

B cell: Antibody production (Total IgG), Memory B cell Antibody Isotypes, Naïve B cells Isotype switching, B cell proliferation/activation/cytokine secretion, Antigen presentation. Tonsillar Organoids

Macrophage: ADCP, MDSC, M1/M2a-d, TAM, effero/phagocytosis, Cytokine Release Assay-predictive toxicity

Dendritic cell: Antigen presentation

Innate Lymphoid Cell: ILC1/2/3 phenotype and cytokine production

Cellular Therapy: Treg (on target assay, cellular persistence, exhaustion, immunogenicity, tumorgenicity)

What Our Partners say about Nexus

Our tailored approach to assay design and execution provides precise solutions for novel therapeutics, ensuring the success of your drug development programme. Visit our testimonial page to read how our immunology CRO services and collaborative efforts have helped our partners achieve quality outcomes to their immunology-focused enquiries.

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